We are excited to share the highlights of the Symposium on Lipedema held in New York City April 17-18, 2015. Top medical researchers, surgeons, physicians, therapists, patients, and advocates from around the world came together in support of finding a cure for this often misunderstood (and misdiagnosed) disease. There were 4 events: the CME course Setting the Research Agenda For Lipedema: Steps Towards a Cure, directed by Mark L. Smith, MD, FACS; a cocktail reception and film premiere for the lipedema documentary, The Disease They Call FAT, a film by filmmaker and patient Catherine Seo, PhD; a Think Tank with 36 professionals and advocates collaboratively setting a research agenda for lipedema; and a Forum for lipedema patients, their supporters and therapists with numerous sessions about lipedema diagnosis, treatment and care.